A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.

@article{Yang2016ANM,
  title={A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2.},
  author={Shouhui Yang and Peijun He and Jian Wang and Aaron J. Schetter and Wei Tang and Naotake Funamizu and Katsuhiko Yanaga and Tadashi Uwagawa and Abhay R Satoskar and Jochen Gaedcke and Markus Bernhardt and B. Michael Ghadimi and Matthias Martin Gaida and Frank Thomas Bergmann and Jens Werner and Thomas Ried and Nader N. Hanna and H. Richard Alexander and S. Perwez Hussain},
  journal={Cancer research},
  year={2016},
  volume={76 13},
  pages={3838-50}
}
Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways that drive disease aggressiveness in tumors with high MIF expression, we analyzed the expression of coding and noncoding genes in high and low MIF-expressing tumors in multiple cohorts of pancreatic ductal adenocarcinoma (PDAC) patients. The key genes and pathways identified were linked to patient survival and were mechanistically… CONTINUE READING