A Novel Isoform of Human Fibroblast Growth Factor 8 Is Induced by Androgens and Associated with Progression of Esophageal Carcinoma

@article{Tanaka2004ANI,
  title={A Novel Isoform of Human Fibroblast Growth Factor 8 Is Induced by Androgens and Associated with Progression of Esophageal Carcinoma},
  author={Shinji Tanaka and Hiroaki Ueo and Ken‐ichi Mafune and Masaki Mori and Jack R Wands and Keizo Sugimachi},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={46},
  pages={1016-1021}
}
Human esophageal carcinomas occur more frequently in males, suggesting that androgens may play a role in the regulation of gene expression associated with malignant transformation. We previously established an androgen-sensitive squamous cell carcinoma line, KSE-1, from a male patient with esophageal cancer; recently a novel isoform of human fibroblast growth factor 8 (FGF8f, isoform FGF8b) was identified and expressed following androgen stimulation of KSE-1 cells. The predicted amino acid… 
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