A Novel Inward Rectifier K+ Channel with Unique Pore Properties

@article{Krapivinsky1998ANI,
  title={A Novel Inward Rectifier K+ Channel with Unique Pore Properties},
  author={Grigory Krapivinsky and Igor Medina and Lily J. Eng and Luba Krapivinsky and Yinhai Yang and David E Clapham},
  journal={Neuron},
  year={1998},
  volume={20},
  pages={995-1005}
}
We have cloned a novel K+-selective, inward rectifier channel that is widely expressed in brain but is especially abundant in the Purkinje cell layer of the cerebellum and pyramidal cells of the hippocampus. It is also present in a wide array of tissues, including kidney and intestine. The channel is only 38% identical to its closest relative, Kir1.3 (Kir1-ATP-regulated inward rectifier K+ [ROMK] family) and displays none of the functional properties unique to the ROMK class. Kir7.1 has several… CONTINUE READING