A Novel Human p53 Isoform Is an Essential Element of the ATR-Intra-S Phase Checkpoint

@article{Rohaly2005ANH,
  title={A Novel Human p53 Isoform Is an Essential Element of the ATR-Intra-S Phase Checkpoint},
  author={Gabor Rohaly and Jan Chemnitz and Silke Dehde and Alejandro Mena Nunez and Jochen Heukeshoven and Wolfgang Deppert and Irena Dornreiter},
  journal={Cell},
  year={2005},
  volume={122},
  pages={21-32}
}
The archetypal human tumor suppressor p53 is considered to have unique transactivation properties. The assumption is based on the fact that additionally identified human p53 isoforms lack transcriptional activity. However, we provide evidence for the existence of an alternatively spliced p53 isoform (Deltap53) that exerts its transcriptional activity independent from p53. In contrast to p53, Deltap53 transactivates the endogenous p21 and 14-3-3sigma but not the mdm2, bax, and PIG3 promoter… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Ordered cooperative func - S dtions of PRMT 1 , p 300 , and CARM 1 in transcriptional activation by p 53

  • R. G. Roeder
  • Cell
  • 2004

ATM and ATR : network cellular responses to DNA amage

  • Y. hiloh
  • Curr . Opin . Genet . Dev .
  • 2001

Similar Papers

Loading similar papers…