A Novel Human Glycoprotein ACA is an Upstream Regulator of Human Hematopoiesis

@article{BeckerKoji2013ANH,
  title={A Novel Human Glycoprotein ACA is an Upstream Regulator of Human Hematopoiesis},
  author={Z. A. Becker-Koji{\'c} and Juan R. Ure{\~n}a-Peralta and Rainer Saffrich and F. J. Rodriguez-Jim{\'e}nez and M. P. Rubio and Pablo R{\'i}os and A. Romero and Anthony Dick Ho and Miodrag Stojkovic},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2013},
  volume={155},
  pages={536-551}
}
A central issue in stem cell biology is a better understanding of the molecular mechanisms that regulate self-renewal of human hematopoietic stem cells (HSCs). Control of the specific function of HSCs like self-renewal and differentiation might be regulated by a common set of critical genes. However, the regulation among these genes is yet to be elucidated. Here, we show that activation by a novel human GPI-linked glycoprotein ACA at the surface of human peripheral blood progenitor cells… 

References

SHOWING 1-10 OF 35 REFERENCES

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

It is shown that the molecular regulation of two critical elements of self-renewal, inhibition of differentiation and induction of proliferation, can be uncoupled, and Notch signaling is identified as a key factor in inhibiting differentiation.

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

The results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs, which are required for haematopoiesis to persist for the lifetime of the animal.

A role for Wnt signalling in self-renewal of haematopoietic stem cells

It is concluded that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and insight is provided into a potential molecular hierarchy of regulation of HSC development.

Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion.

A pharmacological approach to expand normal, functional HSCs in culture using factors that reversibly activate both Wnt/β-catenin and PI3K/Akt signaling simultaneously is developed, showing the necessity of complementary cooperation between the two pathways in promoting self-renewal.

Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells.

It is shown that the continuous presence of TGF-beta 1 directly inhibits the cell division of essentially all low Ho/Rh cells during their 0 to 5th cell division in vitro, which must directly inhibit the proliferation of LTR-HSC contained within these low Ho-Rh cells.

Biology of hematopoietic stem cells and progenitors: implications for clinical application.

Recent rapid advances in understanding the biological nature of hematopoietic stem and progenitor cells have broadened the potential application of these cells in the treatment of diseases.

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

A fusion protein of sIL-6R and IL-6, linked by a flexible peptide chain, that was expressed to high levels was used to effectively expand human hematopoietic progenitor cells ex vivo in a dose dependent fashion.

T-cell reconstitution and expansion after hematopoietic stem cell transplantation: ‘T’ it up!

Clinical trials now demonstrate that it is possible to enhance immune reconstitution after SCT with cytokines or infusions of ex vivo costimulated expanded T cells, supporting the premise that adoptive therapy can accelerate reconstitutes of cellular immunity with enhanced antitumor effects following SCT.

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

Dual-wavelength analysis of Hoechst dye-stained human, rhesus and miniature swine bone marrow cells reveals a small, distinct population of cells that efflux the dye in a manner identical to murine SP cells, suggesting the existence of a hitherto unrecognized population of hematopoietic stem cells that lack the CD34 surface marker classically associated with primitive hematopolietic cells.

A glycophospholipid anchor is required for Qa-2-mediated T cell activation

It is found that antibodies specific for Qa-2, a GPI-anchored class I histocompatibility antigen5, can also activate mouse T cells and strongly indicate that the G PI-anchor is critical for this pathway of T cell activation.