A Novel H+ Conductance in Eosinophils

  title={A Novel H+ Conductance in Eosinophils},
  author={Botond B{\'a}nfi and Jacques Schrenzel and Oliver N{\"u}sse and Daniel P. Lew and Erzs{\'e}bet Ligeti and K T Krause and Nicolas Demaurex},
  journal={The Journal of Experimental Medicine},
  pages={183 - 194}
Efficient mechanisms of H(+) ion extrusion are crucial for normal NADPH oxidase function. However, whether the NADPH oxidase-in analogy with mitochondrial cytochromes-has an inherent H(+) channel activity remains uncertain: electrophysiological studies did not find altered H(+) currents in cells from patients with chronic granulomatous disease (CGD), challenging earlier reports in intact cells. In this study, we describe the presence of two different types of H(+) currents in human eosinophils… CONTINUE READING
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