A Novel Gene Causing a Mendelian Audiogenic Mouse Epilepsy

Abstract

Frings mice are a model of generalized epilepsy and have seizures in response to loud noises. This phenotype is due to the autosomal recessive inheritance of a single gene on mouse chromosome 13. Here we report the fine genetic and physical mapping of the locus. Sequencing of the region led to identification of a novel gene; mutant mice are homozygous for a… (More)
DOI: 10.1016/S0896-6273(01)00397-X

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