A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers.

Abstract

The incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) has increased more than 200% in the past 20 years. Recent genetic sequencing efforts have elucidated relevant genes in head and neck cancer, but HPV-related tumors have consistently shown few DNA mutations. In this study, we sought to analyze alternative splicing events (ASE) that… (More)
DOI: 10.1158/0008-5472.CAN-16-3106

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@article{Guo2017ANF, title={A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers.}, author={Theresa Guo and Akihiro Sakai and Bahman Afsari and Michael J Considine and Ludmila Danilova and Alexander V. Favorov and Srinivasan Thomas Yegnasubramanian and Dylan Z Kelley and Emily Flam and Patrick K. Ha and Zubair Khan and Sarah J. Wheelan and J. Silvio Gutkind and Elana J. Fertig and Daria A. Gaykalova and Joseph A. Califano}, journal={Cancer research}, year={2017}, volume={77 19}, pages={5248-5258} }