A Novel Function of Molecular Chaperone HSP70

@article{Halasi2015ANF,
  title={A Novel Function of Molecular Chaperone HSP70},
  author={M. Halasi and R. V{\'a}raljai and E. Benevolenskaya and A. Gartel},
  journal={The Journal of Biological Chemistry},
  year={2015},
  volume={291},
  pages={142 - 148}
}
The oncogenic transcription factor FOXM1 is overexpressed in the majority of human cancers, and it is a potential target for anticancer therapy. We identified proteasome inhibitors as the first type of drugs that target FOXM1 in cancer cells. Here we found that HSP90 inhibitor PF-4942847 and heat shock also suppress FOXM1. The common effector, which was induced after treatment with proteasome and HSP90 inhibitors or heat shock, was the molecular chaperone HSP70. We show that HSP70 binds to… Expand
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