A Novel Form of Motility in Filopodia Revealed by Imaging Myosin-X at the Single-Molecule Level

@article{Kerber2009ANF,
  title={A Novel Form of Motility in Filopodia Revealed by Imaging Myosin-X at the Single-Molecule Level},
  author={Michael L. Kerber and Damon T. Jacobs and Luke Campagnola and Brian D. Dunn and Taofei Yin and Aurea D Sousa and Omar A. Quintero and Richard E. Cheney},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={967-973}
}
Although many proteins, receptors, and viruses are transported rearward along filopodia by retrograde actin flow, it is less clear how molecules move forward in filopodia. Myosin-X (Myo10) is an actin-based motor hypothesized to use its motor activity to move forward along actin filaments to the tips of filopodia. Here we use a sensitive total internal reflection fluorescence (TIRF) microscopy system to directly visualize the movements of GFP-Myo10. This reveals a novel form of motility at or… CONTINUE READING

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