Corpus ID: 53341622

A Novel Form of Macrophage Function Inhibition by Leishmania mexicana Infection: Involvement in Inhibition of NF-kB Translocation

  title={A Novel Form of Macrophage Function Inhibition by Leishmania mexicana Infection: Involvement in Inhibition of NF-kB Translocation},
  author={Muhannad Shweash},
Manipulation of host cell signalling pathways and pro-inflammatory proteins expression by Leishmania is critical for Leishmania's survival and resultant pathology. Therefore, the characteristics of long time exposure of promastigotes mediated signalling to the MAP kinases, COX-2, iNOS, NO production and NF-κB pathways were investigated in comparison to LPS stimulation. Promastigotes caused no effect on phosphorylation of the three MAP kinases. Unlike outcome was observed on COX-2, iNOS and NO… Expand

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