A Novel Family of Mammalian Taste Receptors

  title={A Novel Family of Mammalian Taste Receptors},
  author={Elliot Adler and Mark A. Hoon and Ken L. Mueller and Jayaram Chandrashekar and Nicholas J. P. Ryba and Charles S. Zuker},

Figures from this paper

Mammalian Sweet Taste Receptors
Identification of a novel member of the T1R family of putative taste receptors
T1R3 maps near the telomere of mouse chromosome’4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice, and displays taste receptor cell‐specific expression.
A candidate taste receptor gene near a sweet taste locus
A candidate taste receptor gene, T1r3, is described that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants.
A transient receptor potential channel expressed in taste receptor cells
Heterologous expression studies of Trpm5 indicate that it functions as a cationic channel that is gated when internal calcium stores are depleted, and may be responsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet compounds.
Elucidation of mammalian bitter taste.
  • W. Meyerhof
  • Biology
    Reviews of physiology, biochemistry and pharmacology
  • 2005
Transgenic expression of a human TAS2R in sweet or bitter taste receptor-expressing cells of mice induced either strong attraction or aversion to the receptor's cognate bitter tastant, suggesting dedicated taste receptor cells appear to function as broadly tuned detectors for bitter substances and are wired to elicit aversive behavior.
Molecular basis of bitter taste
The functional characterization of some of the receptors that these genes encode suggests that it will be possible to understand more precisely their specific functions and to address unresolved questions in bitter taste.
Molecular Functional Interaction between T 2 R Taste Receptors and G-Protein Subunits Expressed in Taste Receptor Cells
The present G 16-based chimeras could be useful tools to analyze the functions of many orphan G-protein-coupled taste receptors.
Taste Receptor Gene Expression Outside the Gustatory System
This review summarizes current knowledge on the occurrence and functional implications of taste receptive molecules outside the oral cavity and examines the roles taste receptors fulfill in vertebrates, which are currently envisioned much broader than thought previously.
The receptors and coding logic for bitter taste
It is demonstrated, using a combination of genetic, behavioural and physiological studies, that T2R receptors are necessary and sufficient for the detection and perception of bitter compounds, and that differences in T2Rs between species can determine the selectivity of bitter taste responses.


A metabotropic glutamate receptor variant functions as a taste receptor
A GPCR cloned from rat taste buds and functionally expressed in CHO cells is described, which shows an unusual concentration–response relationship and the similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate.
Gustducin is a taste-cell-specific G protein closely related to the transducins
A novel G protein α-subunit (α-gustducin) has been identified and cloned from taste tissue, α-Gustducin messenger RNA is expressed in taste buds of all taste papillae (circumvallate, foliate and
Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin.
The alpha-subunit of the trimeric G-protein complex specific for taste receptor cells of the tongue, alpha-gustducin, is described here to be also expressed in the stomach and intestine, providing clues to the long-sought molecular and cellular basis for chemoreception in the gut.
Differential Expression of α-Gustducin in Taste Bud Populations of the Rat and Hamster
The hypothesis that α-gustducin is involved in the transduction of both sweet- and bitter-tasting stimuli by mammalian taste receptor cells is supported.
Chemosensory transduction mechanisms in taste.
Taste receptor cells transduce sweet, sour, salty, and bitter chemicals into receptor potentials that ultimately result in the perception of taste. The mechanisms involved in this process are only
A novel family of genes encoding putative pheromone receptors in mammals
Transduction of bitter and sweet taste by gustducin
Gustducin is a principal mediator of both bitter and sweet signal transduction, and its role in taste transduction is investigated by generating and characterizing mice deficient in the gustducin α-subunit.