A Novel Family of Mammalian Taste Receptors

@article{Adler2000ANF,
  title={A Novel Family of Mammalian Taste Receptors},
  author={E. Adler and M. Hoon and K. Mueller and J. Chandrashekar and N. Ryba and C. Zuker},
  journal={Cell},
  year={2000},
  volume={100},
  pages={693-702}
}
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia. These candidate taste receptors (T2Rs) are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. Notably, a single taste receptor cell expresses a large repertoire of T2Rs, suggesting that each… Expand
1,073 Citations

Paper Mentions

Observational Clinical Trial
The purpose of this study is to help scientists understand how the gut senses ingested nutrients and what kind of processes take place for their absorption in order to establish… Expand
ConditionsDiabetes
InterventionProcedure
Observational Clinical Trial
This study will explore the genetics of taste and taste deficits. The sense of taste plays a crucial role in food choices, allowing people to identify beneficial foods (those with high… Expand
ConditionsHealthy, Taste Disorder
Observational Clinical Trial
This single-site, within-subject experimental basic research study is designed to analyze the hypothesis that allele-specific expression of the bitter taste receptor T2R38 in taste… Expand
ConditionsRhinosinusitis
InterventionOther
Mammalian Sweet Taste Receptors
  • 926
  • PDF
Identification of a novel member of the T1R family of putative taste receptors
  • 279
  • Highly Influenced
A candidate taste receptor gene near a sweet taste locus
  • 391
Elucidation of mammalian bitter taste.
  • W. Meyerhof
  • Medicine, Biology
  • Reviews of physiology, biochemistry and pharmacology
  • 2005
  • 159
Molecular basis of bitter taste
  • 22
  • Highly Influenced
Taste Perception and Coding in Drosophila
  • 337
Taste Receptor Gene Expression Outside the Gustatory System
  • 11
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
A metabotropic glutamate receptor variant functions as a taste receptor
  • 513
  • Highly Influential
  • PDF
Gustducin is a taste-cell-specific G protein closely related to the transducins
  • 543
Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin.
  • 363
  • PDF
Differential Expression of α-Gustducin in Taste Bud Populations of the Rat and Hamster
  • 128
  • PDF
Chemosensory transduction mechanisms in taste.
  • 140
Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans
  • 639
A novel family of genes encoding putative pheromone receptors in mammals
  • 884
Transduction of bitter and sweet taste by gustducin
  • 561
  • Highly Influential
...
1
2
3
4
5
...