A Novel Family of Mammalian Taste Receptors

@article{Adler2000ANF,
  title={A Novel Family of Mammalian Taste Receptors},
  author={Elliot Adler and Mark A. Hoon and Ken L. Mueller and Jayaram Chandrashekar and Nicholas J. P. Ryba and Charles S. Zuker},
  journal={Cell},
  year={2000},
  volume={100},
  pages={693-702}
}
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia. These candidate taste receptors (T2Rs) are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. Notably, a single taste receptor cell expresses a large repertoire of T2Rs, suggesting that each… Expand

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