A Novel Electrical Stimulation Paradigm for the Suppression of epileptiform Activity in an in vivo Model of mesial Temporal Lobe Status Epilepticus

@article{Tang2012ANE,
  title={A Novel Electrical Stimulation Paradigm for the Suppression of epileptiform Activity in an in vivo Model of mesial Temporal Lobe Status Epilepticus},
  author={Yuang Tang and Dominique M. Durand},
  journal={International journal of neural systems},
  year={2012},
  volume={22 3},
  pages={1250006}
}
In this study, we present a novel low-frequency electrical stimulation paradigm for mesial temporal lobe epilepsy (MTLE). The paradigm utilizes the hippocampal commissure as a unique stimulation target to simultaneously influence large portions of the bilateral hippocampal network. When applied to an acute rat model of MTLE, animals that received stimulation exhibited an 88% reduction in the signal power of the bilateral epileptiform activity relative to the control group. In addition, the… CONTINUE READING