A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats

@inproceedings{Nikiforuk2017AND,
  title={A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats},
  author={Agnieszka Nikiforuk and Predrag Kalaba and Marija Ili{\'c} and Volker Korz and Vladimir Draga{\vc}evi{\'c} and Judith Wackerlig and Thierry Langer and Harald Hoeger and Joanna Golebiowska and Piotr Popik and Gert Lubec},
  booktitle={Front. Behav. Neurosci.},
  year={2017}
}
Reduced cognitive abilities are often characterized by an impairment of flexibility, i.e., the ability to switch from learned rules or categories that were important in certain contexts to different new modalities that rule the task. Drugs targeting the dopamine transporter (DAT) are widely used for their potential to enhance cognitive abilities. However, commercially available drugs are of limited specificity for DAT, blocking also noradrenaline and serotonine transporters, that can lead to… CONTINUE READING
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