A Novel DNA Enzyme Reduces Glycosaminoglycan Chains in the Glial Scar and Allows Microtransplanted Dorsal Root Ganglia Axons to Regenerate beyond Lesions in the Spinal Cord

@article{Grimpe2004AND,
  title={A Novel DNA Enzyme Reduces Glycosaminoglycan Chains in the Glial Scar and Allows Microtransplanted Dorsal Root Ganglia Axons to Regenerate beyond Lesions in the Spinal Cord},
  author={Barbara Grimpe and Jerry Silver},
  journal={The Journal of Neuroscience},
  year={2004},
  volume={24},
  pages={1393 - 1397}
}
  • B. Grimpe, J. Silver
  • Published 11 February 2004
  • Biology, Medicine
  • The Journal of Neuroscience
CNS lesions induce production of ECM molecules that inhibit axon regeneration. One major inhibitory family is the chondroitin sulfate proteoglycans (CSPGs). Reduction of their glycosaminoglycan (GAG) chains with chondroitinase ABC leads to increased axon regeneration that does not extend well past the lesion. Chondroitinase ABC, however, is unable to completely digest the GAG chains from the protein core, leaving an inhibitory “stub” carbohydrate behind. We used a newly designed DNA enzyme… Expand
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