A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4

Abstract

The chemokine receptor CCR7 drives leukocyte migration into and within lymph nodes (LNs). It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4. CCR7-dependent navigation is determined by the distribution of extracellular CCL19 and CCL21, which form concentration gradients at specific microanatomical… (More)
DOI: 10.4049/jimmunol.1700377

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@inproceedings{Jafarnejad2017ANC, title={A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4}, author={Mohammad Jafarnejad and David C Zawieja and Bindi S. Brook and Robert J B Nibbs and James E. Moore}, booktitle={Journal of immunology}, year={2017} }