• DOI:10.2174/1871527317666180625101643
• Corpus ID: 49420431

A Novel Combination of ω-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study.

@article{Abdolahi2018ANC,
  title={A Novel Combination of $\omega$-3 Fatty Acids and Nano-Curcumin Modulates Interleukin-6 Gene Expression and High Sensitivity C-reactive Protein Serum Levels in Patients with Migraine: A Randomized Clinical Trial Study.},
  author={Mina Abdolahi and Payam Sarraf and Mohammad Hassan Javanbakht and Niyaz M. Honarvar and Mahsa Hatami and Neda Soveyd and Abbas Tafakhori and Mohsen Sedighiyan and Mona Djalali and Arash Jafarieh and Yousef Masoudian and Mahmoud Djalali},
  journal={CNS \& neurological disorders drug targets},
  year={2018},
  volume={17 6},
  pages={
          430-438
        }
}

• M. Abdolahi, P. Sarraf, +9 authors M. Djalali
• Published 28 August 2018
• Biology, Medicine
• CNS & neurological disorders drug targets

BACKGROUND
Migraine is a disabling neuroinflammatory condition characterized by increasing the levels of interleukin (IL)-6, a proinflammatory cytokine and C-reactive protein (CRP) which considered as a vascular inflammatory mediator, disrupting the integrity of blood-brain barrier and contributing to neurogenic inflammation, and disease progression. Curcumin and ω-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels. The aim of present study is the evaluation of combined effects of ω-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients.

METHODS
Eighty episodic migraine patients enrolled in the trial and were divided into four groups as 1) combination of ω-3 fatty acids (2500 mg) plus nano-curcumin (80 mg), 2) ω-3 (2500 mg), 3) nanocurcumin (80 mg), and 4) the control (ω-3 and nano-curcumin placebo included oral paraffin oil) over a two-month period. At the beginning and the end of the study, the expression of IL-6 from peripheral blood mononuclear cells and IL-6 and hs-CRP serum levels were measured, using a real-time PCR and ELISA methods, respectively.

RESULTS
The results showed that both of ω-3 and nano-curcumin down-regulated IL-6 mRAN and significantly decreased the serum concentration. hs-CRP serum levels significantly decrease in combination and nano-curcumin within groups (P<0.05). An additive greater reduction of IL-6 and hs-CRP was observed in the combination group suggested a possible synergetic relation.

CONCLUSION
It seems that ω-3 fatty acids and curcumin supplementation can be considered a new promising target in migraine prevention.