A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance

@article{Shen2018ANC,
  title={A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance},
  author={Linyuan Shen and Mailin Gan and Zhen-dong Tan and Dongmei Jiang and Yanzhi Jiang and Mingzhou Li and Jinyong Wang and Xuewei Li and Shunhua Zhang and Li Zhu},
  journal={Biomolecules},
  year={2018},
  volume={8}
}
tRNA-derived fragments (tRFs) are a new class of non-coding RNA that play an important role in regulating cellular RNA processing and protein translation. However, there is currently no study reporting the influence of tRFs on myocardial hypertrophy. In this study, we used an isoproterenol (ISO)-induced myocardial hypertrophy rat model. Small RNA (<40 nts) transcriptome sequencing was used to select differentially expressed tRFs. We also compared the tRFs expression pattern in F0 sperm and the… 

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