A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of Klebsiella pneumoniae and Pseudomonas aeruginosa

@article{OcampoIbez2020ANC,
  title={A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of Klebsiella pneumoniae and Pseudomonas aeruginosa},
  author={Iv{\'a}n Dar{\'i}o Ocampo-Ib{\'a}{\~n}ez and Yamil Liscano and Sandra Patricia Rivera-S{\'a}nchez and Jos{\'e} O{\~n}ate-Garz{\'o}n and Ashley Dayan Lugo-Guevara and Liliana Janeth Fl{\'o}rez-Elvira and Maria Cristina Lesmes},
  journal={Evolutionary Bioinformatics Online},
  year={2020},
  volume={16}
}
Infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa and Klebsiella pneumoniae are a serious worldwide public health concern due to the ineffectiveness of empirical antibiotic therapy. Therefore, research and the development of new antibiotic alternatives are urgently needed to control these bacteria. The use of cationic antimicrobial peptides (CAMPs) is a promising candidate alternative therapeutic strategy to antibiotics because they exhibit antibacterial activity against… Expand
3 Citations
Antibacterial Activity of a Cationic Antimicrobial Peptide against Multidrug-Resistant Gram-Negative Clinical Isolates and Their Potential Molecular Targets
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This review highlights the novel sources of AMPs with high antimicrobial activities, including the entomopathogenic nematode/bacterium (EPN/EPB) symbiotic complex and the design of peptidomimetic antimicrobial agents that can complement the defects of therapeutic peptides have been used as a template. Expand
Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria
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The importance of antimicrobial peptides and their successful activity against critical and high-priority bacteria published in the WHO list is examined. Expand

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