A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of Klebsiella pneumoniae and Pseudomonas aeruginosa

  title={A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of Klebsiella pneumoniae and Pseudomonas aeruginosa},
  author={Iv{\'a}n Dar{\'i}o Ocampo-Ib{\'a}{\~n}ez and Yamil Liscano and Sandra Patricia Rivera-S{\'a}nchez and Jos{\'e} O{\~n}ate-Garz{\'o}n and Ashley Dayan Lugo-Guevara and Liliana Janeth Fl{\'o}rez-Elvira and Maria Cristina Lesmes},
  journal={Evolutionary Bioinformatics Online},
Infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa and Klebsiella pneumoniae are a serious worldwide public health concern due to the ineffectiveness of empirical antibiotic therapy. Therefore, research and the development of new antibiotic alternatives are urgently needed to control these bacteria. The use of cationic antimicrobial peptides (CAMPs) is a promising candidate alternative therapeutic strategy to antibiotics because they exhibit antibacterial activity against… Expand
3 Citations
Antibacterial Activity of a Cationic Antimicrobial Peptide against Multidrug-Resistant Gram-Negative Clinical Isolates and Their Potential Molecular Targets
The interaction between the peptide and genomic DNA (gDNA) showed a hyperchromic effect, which indicates that ΔM2 can denature bacterial DNA strands via the grooves. Expand
Antimicrobial Peptides: Novel Source and Biological Function With a Special Focus on Entomopathogenic Nematode/Bacterium Symbiotic Complex
This review highlights the novel sources of AMPs with high antimicrobial activities, including the entomopathogenic nematode/bacterium (EPN/EPB) symbiotic complex and the design of peptidomimetic antimicrobial agents that can complement the defects of therapeutic peptides have been used as a template. Expand
Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria
The importance of antimicrobial peptides and their successful activity against critical and high-priority bacteria published in the WHO list is examined. Expand


Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa
This study showed the potent and rapid antibacterial activity of CAMPs on both laboratory and clinical isolates of S. aureus and P. aeruginosa either susceptible or resistant to antibiotics. Expand
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation.
Q53 CecB is a promising candidate in the development of CecB-derived compounds against P. aeruginosa and is suggested to represent a critical factor in stabilizing the hydrophobic segment that interacts with the bacterial membrane, determining the highest antimicrobial activity of the whole peptide. Expand
In Vitro Activities of Antibiotics and Antimicrobial Cationic Peptides Alone and in Combination against Methicillin-Resistant Staphylococcus aureus Biofilms
AMPs seem to be good candidates for further investigations in the treatment of MRSA biofilms, alone or in combination with antibiotics, and use of a combination of antimicrobial agents may help prevent or delay the emergence of resistance. Expand
Activity of Cecropin A-Melittin Hybrid Peptides against Colistin-Resistant Clinical Strains of Acinetobacter baumannii: Molecular Basis for the Differential Mechanisms of Action
The results argue in favor of a possible use of CA-M peptides, and by extension other antimicrobial peptides with similar features, as alternative chemotherapy in colistin-resistant Acinetobacter infections. Expand
Insect Cecropins, Antimicrobial Peptides with Potential Therapeutic Applications
This work reports several data suggesting that Cec and Cec-analog peptides are promising antibacterial therapeutic candidates, including their low toxicity against mammalian cells, and anti-inflammatory activity. Expand
Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp.
Three of the synthetic AMPs designed and synthesised showed higher antimicrobial activity and selectivity against a broad spectrum of Gram-positive and Gram-negative bacteria compared with the naturally occurring AMPs magainin 2a and pleurocidin. Expand
Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies.
The mechanism of antibiotic resistance in P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. Expand
High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and β-Lactamase Encoding Genes in a Brazilian Intensive Care Unit
The wide variety of MDR K. pneumoniae harboring β-lactams and virulence genes strongly suggest a necessity for the implementation of effective strategies to prevent and control the spread of antibiotic resistant infections. Expand
A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties
Interactions between cecropin DH and the highly anionic lipopolysaccharide (LPS) component of the Gram-negative bacterial outer membrane indicate that it is capable of dissociating LPS micelles and disrupting LPS aggregates into smaller assemblies, which may play a vital role in its antimicrobial activity. Expand
Developments on antibiotics for multidrug resistant bacterial Gram-negative infections
The recent introduction of new antibiotics into clinical practice is an encouraging step after a long period of pipeline stagnation, however, most of the new compounds are based on modifications of traditional antibiotic structures challenging their longevity as therapeutic options. Expand