A Novel Canine Model of Portal Vein Stenosis Plus Thioacetamide Administration-Induced Cirrhotic Portal Hypertension With Hypersplenism

@article{Lin2011ANC,
  title={A Novel Canine Model of Portal Vein Stenosis Plus Thioacetamide Administration-Induced Cirrhotic Portal Hypertension With Hypersplenism},
  author={Dexin Lin and Xianbin Wu and Xiaoke Ji and Qi-yu Zhang and Yuanwei Lin and Weijian Chen and Wangxun Jin and Liming Deng and Yunzhi Chen and Bicheng Chen and Jianmin Li},
  journal={Cell Biochemistry and Biophysics},
  year={2011},
  volume={62},
  pages={245-255}
}
Current large animal models that could closely resemble the typical features of cirrhotic portal hypertension in human have not been well established. Thus, we aimed to develop and describe a reliable and reproducible canine cirrhosis model of portal hypertension. A total of 30 mongrel dogs were randomly divided into four groups: 1 (control; n = 5), 2 (portal vein stenosis [PVS]; n = 5], 3 (thioacetamide [TAA]; n = 5), and 4 (PVS plus TAA; n = 15). After 4-months modeling period, liver and… CONTINUE READING