A Novel Beta-Defensin Antimicrobial Peptide in Atlantic Cod with Stimulatory Effect on Phagocytic Activity

@inproceedings{Ruangsri2013ANB,
  title={A Novel Beta-Defensin Antimicrobial Peptide in Atlantic Cod with Stimulatory Effect on Phagocytic Activity},
  author={Jareeporn Ruangsri and Yoichiro Kitani and Viswanath Kiron and Jep Lokesh and Monica Fengsrud Brinchmann and B{\aa}rd Ove Karlsen and Jorge M O Fernandes},
  booktitle={PloS one},
  year={2013}
}
A novel defensin antimicrobial peptide gene was identified in Atlantic cod, Gadus morhua. This three exon/two intron defensin gene codes for a peptide precursor consisting of two domains: a signal peptide of 26 amino acids and a mature peptide of 40 residues. The mature cod defensin has six conserved cysteine residues that form 1-5, 2-4 and 3-6 disulphide bridges. This pattern is typical of beta-defensins and this gene was therefore named cod beta-defensin (defb). The tertiary structure of Defb… CONTINUE READING