A Novel Anticancer Therapy That Simultaneously Targets Aberrant p53 and Notch Activities in Tumors

Abstract

Notch signaling pathway plays an important role in tumorigenesis by maintaining the activity of self-renewal of cancer stem cells, and therefore, it is hypothesized that interference of Notch signaling may inhibit tumor formation and progression. H101 is a recombinant oncolytic adenovirus that is cytolytic in cells lacking intact p53, but it is unable to… (More)
DOI: 10.1371/journal.pone.0046627

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