A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells

@inproceedings{Klimczak2009ANA,
  title={A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat M{\"u}ller Cells},
  author={Ryan R. Klimczak and James T Koerber and Deniz Dalkara and John G Flannery and David V. Schaffer},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND The pathologies of numerous retinal degenerative diseases can be attributed to a multitude of genetic factors, and individualized treatment options for afflicted patients are limited and cost-inefficient. In light of the shared neurodegenerative phenotype among these disorders, a safe and broad-based neuroprotective approach would be desirable to overcome these obstacles. As a result, gene delivery of secretable-neuroprotective factors to Müller cells, a type of retinal glia that… CONTINUE READING
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