A Nonparametric Pharmacokinetic Approach to Determine the Optimal Dosing Regimen for 30-Minute and 3-Hour Meropenem Infusions in Critically Ill Patients.

Abstract

BACKGROUND Pharmacokinetics of meropenem differ widely in the critically ill population. It is imperative to maintain meropenem concentrations above the inhibitory concentrations for most of the interdose interval. A population pharmacokinetic/pharmacodynamic model was developed to determine the probability of target attainment for 3-hour and 30-minute… (More)
DOI: 10.1097/FTD.0000000000000323

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@article{Mathew2016ANP, title={A Nonparametric Pharmacokinetic Approach to Determine the Optimal Dosing Regimen for 30-Minute and 3-Hour Meropenem Infusions in Critically Ill Patients.}, author={Sumith K Mathew and Binu Susan Mathew and Michael Neely and Girish S. Naik and Ratna Prabha and Gijoe George Jacob and Subramani K and Denise Helen Fleming}, journal={Therapeutic drug monitoring}, year={2016}, volume={38 5}, pages={593-9} }