A Nonparametric Approach to Estimating Divergence Times in the Absence of Rate Constancy

  title={A Nonparametric Approach to Estimating Divergence Times in the Absence of Rate Constancy},
  author={M. Sanderson},
  journal={Molecular Biology and Evolution},
  • M. Sanderson
  • Published 1997
  • Biology
  • Molecular Biology and Evolution
  • A new method for estimating divergence times when evolutionary rates are variable across lineages is proposed. The method, called nonparametric rate smoothing (NPRS), relies on minimization of ancestor-descendant local rate changes and is motivated by the likelihood that evolutionary rates are autocorrelated in time. Fossil information pertaining to minimum and/or maximum ages of nodes in a phylogeny is incorporated into the algorithms by constrained optimization techniques. The accuracy of… CONTINUE READING
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