A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

  title={A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion},
  author={Michael G Overholtzer and Arnaud Andr{\'e} Mailleux and Ghassan Mouneimne and Guillaume Normand and Stuart J. Schnitt and Randall W. King and Edmund S Cibas and Joan S. Brugge},
Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell death program termed anoikis. Here we describe a nonapoptotic cell death program in matrix-detached cells that is initiated by a previously unrecognized and unusual process involving the invasion of one cell into another, leading to a transient state in which a live cell is contained within a neighboring host cell. Live internalized cells are either degraded by lysosomal enzymes or released. We term… CONTINUE READING
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  • A. P. Gilmore
  • Cell Death Differ. 12 (Suppl 2), 1473–1477.
  • 2005
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