A Non Mouse-Adapted Dengue Virus Strain as a New Model of Severe Dengue Infection in AG129 Mice

@inproceedings{Tan2010ANM,
  title={A Non Mouse-Adapted Dengue Virus Strain as a New Model of Severe Dengue Infection in AG129 Mice},
  author={Grace Kx Tan and Jowin Kai Wei Ng and Scott Lee Trasti and Wouter Schul and George Yip and S. Miguel Alonso},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
The spread of dengue (DEN) worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the lack of a suitable small animal model. Most of the DEN clinical isolates and cell culture-passaged DEN virus strains reported so far require either host adaptation, inoculation with a high dose and/or… CONTINUE READING