A Non-Death Role of the Yeast Metacaspase: Yca1p Alters Cell Cycle Dynamics

@article{Lee2008ANR,
  title={A Non-Death Role of the Yeast Metacaspase: Yca1p Alters Cell Cycle Dynamics},
  author={Robin E. C. Lee and Lawrence G. Puente and Mads K{\ae}rn and Lynn A. Megeney},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1463 - 1467}
}
Caspase proteases are a conserved protein family predominantly known for engaging and executing apoptotic cell death. Nevertheless, in higher eukaryotes, caspases also influence a variety of cell behaviors including differentiation, proliferation and growth control. S. cerevisiae expresses a primordial caspase, yca1, and exhibits apoptosis-like death under certain stresses; however, the benefit of a dedicated death program to single cell organisms is controversial. In the absence of a clear… CONTINUE READING

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