A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

@article{Imamura2008ANF,
  title={A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis},
  author={Shintaro Imamura and Junzō Uchiyama and Eriko Koshimizu and Jun-ichi Hanai and Christina Raftopoulou and Ryan D. Murphey and Peter Bayliss and Yoichi Imai and Caroline Erter Burns and Kenkichi Masutomi and Sarantis Gagos and Leonard I. Zon and Thomas M Roberts and Shuji Kishi},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={661 - 673}
}
Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. To further examine the role of telomerase during vertebrate development, the zebrafish telomerase reverse transcriptase (zTERT) was functionally characterized. Upon zTERT knockdown, zebrafish embryos show reduced telomerase activity and are viable, but develop… CONTINUE READING
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