A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.

@article{Nol2013ANA,
  title={A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.},
  author={Emily S No{\"e}l and Manon C. Verhoeven and Anne Karine Lagendijk and Federico Tessadori and Kelly Smith and Suma Choorapoikayil and Jeroen den Hertog and Jeroen Bakkers},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2754}
}
Breaking left-right symmetry in bilateria is a major event during embryo development that is required for asymmetric organ position, directional organ looping and lateralized organ function in the adult. Asymmetric expression of Nodal-related genes is hypothesized to be the driving force behind regulation of organ laterality. Here we identify a Nodal-independent mechanism that drives asymmetric heart looping in zebrafish embryos. In a unique mutant defective for the Nodal-related southpaw gene… CONTINUE READING
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