A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.

@article{Doukov2002ANC,
  title={A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.},
  author={Tzanko I. Doukov and T M Iverson and Javier G. Seravalli and Stephen W Ragsdale and Catherine L Drennan},
  journal={Science},
  year={2002},
  volume={298 5593},
  pages={567-72}
}
A metallocofactor containing iron, sulfur, copper, and nickel has been discovered in the enzyme carbon monoxide dehydrogenase/acetyl-CoA (coenzyme A) synthase from Moorella thermoacetica (f. Clostridium thermoaceticum). Our structure at 2.2 angstrom resolution reveals that the cofactor responsible for the assembly of acetyl-CoA contains a [Fe4S4] cubane… CONTINUE READING