A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast

@article{Vernis2009ANI,
  title={A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast},
  author={Laurence Vernis and C{\'e}line Facca and Emmanuelle Delagoutte and Nicolas Soler and Roland Chanet and Bernard Guiard and G{\'e}rard Faye and Giuseppe Baldacci},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={337 - 350}
}
A mutated allele of the essential gene TAH18 was previously identified in our laboratory in a genetic screen for new proteins interacting with the DNA polymerase delta in yeast [1]. The present work shows that Tah18 plays a role in response to oxidative stress. After exposure to lethal doses of H(2)O(2), GFP-Tah18 relocalizes to the mitochondria and controls mitochondria integrity and cell death. Dre2, an essential Fe/S cluster protein and homologue of human anti-apoptotic Ciapin1, was… CONTINUE READING

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