• Corpus ID: 37333453

A New and Sensitive LC-MS/MS Method for the Determination of Clopidogrel in Human Plasma

@inproceedings{Bibire2014ANA,
  title={A New and Sensitive LC-MS/MS Method for the Determination of Clopidogrel in Human Plasma},
  author={Nela Bibire and Mădălina Vieriu and Gladiola Ț{\^a}ntaru and Mihai Apostu and Luminița Agoroaei and Alina Diana Panainte and Alexandru Znagovan and Aurelian Vlase and Grigore T. Popa},
  year={2014}
}
→ → → → 212.1, for clopidogrel and m/z 327 → 217, for clopidogrel-d3, in multiple reaction monitoring mode (MRM). The plasma samples were buffered (pH 2.0), extracted using a mixture hexan-ethyl acetate and then 10μL of the sample extract was injected into the LC-MS/MS system. Clopidogrel and the internal standard were separated on a Zorbax SB-C8 column using a mobile phase consisting of 50:50 (v/v) mixture of acetonitrile and 0.1% formic acid aqueous solution, with a flow rate of 1 mL/min. The… 
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