A New UAG-Encoded Residue in the Structure of a Methanogen Methyltransferase

@article{Hao2002ANU,
  title={A New UAG-Encoded Residue in the Structure of a Methanogen Methyltransferase},
  author={B. Hao and W. Gong and T. Ferguson and C. James and J. Krzycki and M. Chan},
  journal={Science},
  year={2002},
  volume={296},
  pages={1462 - 1466}
}
Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkerimonomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead… Expand
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