A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia

@article{Sheikh2015ANT,
  title={A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia},
  author={Saifuddin Sheikh and Ateeq Ahmad and Shoukath M. Ali and Moghis U. Ahmad and Mahesh Paithankar and Dipak Saptarshi and Prashant Bhimrao Kale and Kirti Bansidhar Maheshwari and Hemant V Barkate and Pathak Hl and Mohammad Mushtaq and Imran Ahmad},
  journal={Journal of clinical \& experimental dermatology research},
  year={2015},
  volume={6},
  pages={1-6}
}
Objectives: To compare the safety and efficacy of MorrF (combination of Minoxidil [5%]+Finasteride [0.1%] lipid solution) with Minoxidil (5%) solution in adult male patients suffering from Androgenetic Alopecia (AGA). Background: AGA is one of the three most common forms of non-scarring alopecia with approximately 95% of hair loss cases in men and women. Fifty percent of men by age 50 years exhibit some degree of AGA. Currently there are two effective treatments available for the treatment of… 

Figures and Tables from this paper

Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature
TLDR
Topical finasteride is a promising therapeutic option that aims to decrease complications caused by oral administration and is emphasize the importance of continued research for the establishment of a novel therapeutic agent.
The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-analysis
TLDR
In patients with AGA, the combination treatment of finasteride and topical minoxidil has better therapeutic efficacy than and similar safety as monotherapy, however, the best concentration of combination treatment requires further studies with sound methodological quality.
Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study
TLDR
A topical combination of 0.25% finasteride and 3% minoxidil may be a promising option in the treatment of FPHL with an additional benefit of increasing hair diameter, Nevertheless, as it may be absorbed percutaneously, it should be reserved for postmenopausal women.
Review of selected endpoints in studies evaluating the effectiveness and efficacy of topical finasteride use for androgenetic alopecia
TLDR
This review highlighted the available tools of hair evaluation in the reviewed literature and found assessment methods were inconsistently applied across the reviewed studies, which led to results that are hard to combine statistically.
An overview of herbal alternatives in androgenetic alopecia
TLDR
This article focuses on herbs which can be used in AGA and the role of herbal drugs to have the action against 5‐alpha‐reductase enzyme inhibiting it and reducing the hair loss.
The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis
TLDR
It is suggested that combination therapy could be an effective, safe and promising option for the treatment of AGA, however, more RCTs are needed to further investigate and confirm the efficacy of combined treatment.
The Efficacy of Ostrich Antibodies to Dihydrotestosterone and 5α-Reductase in the Restoration of Hair Growth
TLDR
In all instances but one, the subjects had a hair-growth effect about 3 months after the antibody was applied to the scalp, and the study participants with hair growth were pleased with the results and with the ease of use of the antibody solution.
Physiological and Histological Study of the Effect of Finasteride Drug (Prostacare) on the Fertility of Albino Male Rats
TLDR
A significant decrease in the body, testis, epididymis and prostate gland weightsin compared with the control group and necrosis in the seminiferous tubules of the testis was showed.
Experimental and early investigational drugs for androgenetic alopecia
TLDR
It is proposed that topically applied medications, or intra-dermal injected or implanted materials, are preferable treatment modalities, minimizing side effect risks as compared to systemically applied treatments.
Effects of Trichosol TM on Increasing the Anagen Phase of the Capillary Cycle of Volunteers
TLDR
The results indicated that after treatment for 90 days with the combination of Minoxidil (3%) and TrichosolTM, both sexes presented increase in the percentage of anagen phase, which could be useful in the development of new therapeutic associations for the treatment of hair loss.
...
1
2
3
...

References

SHOWING 1-10 OF 15 REFERENCES
An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia
TLDR
Both drugs were effective and safe in the treatment of mild to severe AGA, although oral finasteride treatment was more effective (p < 0.05); side effects were all mild, and there was no need to stop the treatment.
Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily.
TLDR
Hair weight increased to a larger extent than hair count, implying that factors other than the number of hairs, such as increased growth rate (length and thickness of hairs) contribute to the beneficial effects of finasteride in treated men.
Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men
TLDR
It is inferred that the therapeutic efficacy is enhanced by combining the two drugs acting on different aetiological aspects of AGA by combining finasteride alone or in combination with minoxidil or ketoconazole.
Efficacy and safety of 3% minoxidil versus combined 3% minoxidil / 0.1% finasteride in male pattern hair loss: a randomized, double-blind, comparative study.
  • C. Tanglertsampan
  • Medicine
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • 2012
TLDR
Although change of hair counts was not statistically different between two groups, global photographic assessment showed significantly greater improvement in the MFX group than the MNX group, suggesting that MFX may be a safe and effective treatment option.
Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course
TLDR
The clinical outcome, in terms of both hair regrowth and balding areas reduction, seems to be encouraging, in the absence of either any evidence of percutaneous absorption of finasteride, or local/systemic untoward effects.
Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.
TLDR
Inhibition of the conversion of T to DHT by this 5 alpha-reductase inhibitor reverses the balding process and enhances hair regrowth by topical minoxidil in the male balding stumptail macaque monkeys.
Male androgenetic alopecia
TLDR
Androgenetic alopecia is a progressive condition and although the current available treatments are effective in arresting the progression of the disease, they allow only partial regrowth of hair at its best.
Hair follicle biology and topical minoxidil: possible mechanisms of action.
TLDR
It is concluded that the most probable site for the action of minoxidil is on the specialized mesenchymal cells of the follicular dermal papilla.
Male pattern androgenetic alopecia
TLDR
This article is based largely on the experience in the management of hair loss, and the pathogenesis and genetic basis of the hair loss have been better understood, as has the distress experienced by men who have lost their hair.
...
1
2
...