A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model

@inproceedings{Nagaoka2015ANT,
  title={A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model},
  author={Kazuhiro Nagaoka and Tetsuya Matoba and Yajing Mao and Yasuhiro Nakano and Gentaro Ikeda and Shizuka Egusa and Masaki Tokutome and Ryoji Nagahama and Kaku Nakano and Kenji Sunagawa and Kensuke Egashira and John Calvert},
  booktitle={PloS one},
  year={2015}
}
AIM There is an unmet need to develop an innovative cardioprotective modality for acute myocardial infarction (AMI), for which the effectiveness of interventional reperfusion therapy is hampered by myocardial ischemia-reperfusion (IR) injury. Pretreatment with statins before ischemia is shown to reduce MI size in animals. However, no benefit was found in animals and patients with AMI when administered at the time of reperfusion, suggesting insufficient drug targeting into the IR myocardium… CONTINUE READING