A New Synthesis of TE2A—a Potential Bifunctional Chelator for 64Cu

@article{Pandya2010ANS,
  title={A New Synthesis of TE2A—a Potential Bifunctional Chelator for 64Cu},
  author={Darpan N Pandya and Jung Young Kim and Wonjung Kwak and Jeong Chan Park and Manoj B Gawande and Gwang Il An and Eun Kyoung Ryu and Jeongsoo Yoo},
  journal={Nuclear Medicine and Molecular Imaging},
  year={2010},
  volume={44},
  pages={185-192}
}
PurposeThe development of a new bifunctional chelator, which holds radiometals strongly in living systems, is a prerequisite for the successful application of disease-specific biomolecules to medical diagnosis and therapy. Recently, TE2A was reported to make kinetically more stable Cu(II) complexes than TETA. Herein, we report a new synthetic route to TE2A and explore its potential as a bifunctional chelator.MethodsTE2A was synthesized using the regioselective alkylation of benzyl bromoacetate… CONTINUE READING