A New Staining Method (oto) for Enhancing Contrast of Lipid-containing Membranes and Droplets in Osmium Tetroxide-fixed Tissue with Osmiophilic Thiocarbohydrazide (tch)

@article{Seligman1966ANS,
  title={A New Staining Method (oto) for Enhancing Contrast of Lipid-containing Membranes and Droplets in Osmium Tetroxide-fixed Tissue with Osmiophilic Thiocarbohydrazide (tch)},
  author={Arnold M. Seligman and Hannah L. Wasserkrug and Jacob S. Hanker},
  journal={The Journal of Cell Biology},
  year={1966},
  volume={30},
  pages={424 - 432}
}
Al though the in t roduct ion of fixation of tissue with osmium tetroxide by Palade (8) ushered in the modern era of electron microscopy of biological materials, a need for greater contrast and greater resolution in visualizing membranous structures has s t imulated the in t roduct ion of methods for staining with heavy metal salts, in order to enhance the del ineat ion of the fine archi tecture of cells. This is especially necessary because of the poor contras t of osmium tetroxide-fixed… CONTINUE READING

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Proceedings of the 2nd International Congress for Histochemistry and Cytochemistry, t3erlin

  • A. M. SELIaMAN
  • 1964

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