A New Role for Clathrin Adaptor Proteins 1 and 3 in Lipoplex Trafficking

@inproceedings{Alford2014ANR,
  title={A New Role for Clathrin Adaptor Proteins 1 and 3 in Lipoplex Trafficking},
  author={Justine E. Alford and Jade Gumbs and Emma C Anderson},
  booktitle={PloS one},
  year={2014}
}
Intracellular protein trafficking through secretory and endocytic pathways depends on the function of adaptor proteins that bind motifs on cargo proteins. The adaptor proteins then recruit coat proteins such as clathrin, enabling the formation of a transport vesicle. While studying the role of the clathrin adaptor proteins, AP-1, AP-2 and AP-3 in viral protein trafficking, we discovered that AP-1 and AP-3 potentially have a role in successful transfection of mammalian cells with DNA-liposome… CONTINUE READING