A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.

  title={A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.},
  author={Warren C. Ladiges and Jessica M. Snyder and Alireza Aghashahi and Denise M Imai and Tim P. Snider and Xuan Ge and M{\'a}rcia Aparecida Ciol and Christina Pettan-Brewer and Smitha P S Pillai and John Frederick Morton and Ellen K. Quarles and Peter Rabinovitch and Laura J. Niedernhofer and Denny H. Liggitt},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  volume={72 6},
Testing drugs for anti-aging effects has historically been conducted in mouse life-span studies, but are costly and time consuming, and more importantly, difficult to recapitulate in humans. In addition, life-span studies in mice are not well suited to testing drug combinations that target multiple factors involved in aging. Additional paradigms for testing therapeutics aimed at slowing aging are needed. A new paradigm, designated as the Geropathology Grading Platform (GGP), is based on a… CONTINUE READING

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