A New Potent Analgetic Antagonist

@article{Gordon1961ANP,
  title={A New Potent Analgetic Antagonist},
  author={M. Gordon and J. Lafferty and D. H. Tedeschi and N. B. Eddy and E. May},
  journal={Nature},
  year={1961},
  volume={192},
  pages={1089-1089}
}
THE discovery of a new potent analgetic with a reduced liability to addiction1 in the benzomorphan series, namely, 2′-hydroxy-5,9-dimethyl-2-phenylethyl-6,7-benzomorphan2 (I), has suggested further work in the series. 2′-Hydxoxy-5,9-dimethyl-2-allyl-6,7-benzomorphan (III) is a potent antagonist of phenazocine, morphine, meperidine, and other analgetic agents. This compound is of special interest in that combinations of phenazocine and III in ratios of 5 : 1 to 100 : 1 retain analgetic activity… Expand
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