A New Orally Bioavailable Synthetic Androstene Inhibits Collagen‐Induced Arthritis in the Mouse

@article{Auci2007ANO,
  title={A New Orally Bioavailable Synthetic Androstene Inhibits Collagen‐Induced Arthritis in the Mouse},
  author={Dominick L Auci and Laurie J. Kaler and Sandhya Subramanian and Yu-Shen Huang and James M. Frincke and Christopher L Reading and Halina Offner},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1110}
}
  • D. Auci, L. Kaler, H. Offner
  • Published 1 September 2007
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract:  Dehydroepiandrosterone (DHEA) has attracted much interest because of its many antiaging, metabolic and immune‐modulating effects in rodents. Synthetic derivatives, such as 5‐androstene‐16α‐fluoro‐17‐one (HE2500) and certain natural metabolites also provide benefit in various animal models of autoimmune and metabolic diseases. But, like DHEA, low potency and low oral bioavailability suggested limited usefulness of these compounds in humans. We hypothesized that HE3286, a novel 17… 
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