A New Orally Bioavailable Synthetic Androstene Inhibits Collagen‐Induced Arthritis in the Mouse

  title={A New Orally Bioavailable Synthetic Androstene Inhibits Collagen‐Induced Arthritis in the Mouse},
  author={Dominick L Auci and Laurie J. Kaler and Sandhya Subramanian and Yu-Shen Huang and James M. Frincke and Christopher L Reading and Halina Offner},
  journal={Annals of the New York Academy of Sciences},
  • D. Auci, L. Kaler, H. Offner
  • Published 1 September 2007
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract:  Dehydroepiandrosterone (DHEA) has attracted much interest because of its many antiaging, metabolic and immune‐modulating effects in rodents. Synthetic derivatives, such as 5‐androstene‐16α‐fluoro‐17‐one (HE2500) and certain natural metabolites also provide benefit in various animal models of autoimmune and metabolic diseases. But, like DHEA, low potency and low oral bioavailability suggested limited usefulness of these compounds in humans. We hypothesized that HE3286, a novel 17… 
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Effects of Synthetic Anti-Inflammatory Sterol in CB3V-Induced Myocarditis: A Morphological Study on Heart Muscle Tissue
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Molecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome
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17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain


The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis
The utility of WAY-169916, and other compounds in its class, in treating RA through global suppression of inflammation via selective blockade of NF-κB transcriptional activity is suggested.
Ergosteroids. VI. Metabolism of dehydroepiandrosterone by rat liver in vitro: a liquid chromatographic-mass spectrometric study.
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  • Biology, Chemistry
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2002
Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice
In vivo administration of DHEA significantly reduced the severity and incidence of acute EAE, along with a decrease in demyelination/inflammation and expressions of (pro)inflammatory cytokines in the CNS.
Anti-Hypercholesterolemic Effect of Dehydroepiandrosterone in Rats
It seems that the anti-hypercholesterolemic effect of DHA cannot be explained by a thyromimetic activity, and these findings are of clinical importance since DHA, which is a weak endogenous androgen, is orally active as an anti- hypercholesterolesmic agent.
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells, and suggests a potential new mechanism by which they exert positive and negative effects.
Characterization of a peptide analog of a determinant of type II collagen that suppresses collagen-induced arthritis.
It is concluded that analogue peptide A9 is effective in suppressing established CIA by inducing T cells to produce a Th2 cytokine pattern in response to CII.
The influence of testosterone on the development of autoimmune thyroiditis in thymectomized and irradiated rats.
Results indicate that sex steroid hormones have an important modulatory influence on the genesis of autoimmune thyroiditis and it is apparent in this particular model that this influence can be demonstrated in the absence of the thymus gland.