A New Orally Bioavailable Synthetic Androstene Inhibits Collagen‐Induced Arthritis in the Mouse
@article{Auci2007ANO, title={A New Orally Bioavailable Synthetic Androstene Inhibits Collagen‐Induced Arthritis in the Mouse}, author={Dominick L Auci and Laurie J. Kaler and Sandhya Subramanian and Yu-Shen Huang and James M. Frincke and Christopher L Reading and Halina Offner}, journal={Annals of the New York Academy of Sciences}, year={2007}, volume={1110} }
Abstract: Dehydroepiandrosterone (DHEA) has attracted much interest because of its many antiaging, metabolic and immune‐modulating effects in rodents. Synthetic derivatives, such as 5‐androstene‐16α‐fluoro‐17‐one (HE2500) and certain natural metabolites also provide benefit in various animal models of autoimmune and metabolic diseases. But, like DHEA, low potency and low oral bioavailability suggested limited usefulness of these compounds in humans. We hypothesized that HE3286, a novel 17…
31 Citations
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Oral treatment with HE3286 favourably influenced the course of arthritis in the rat model of adjuvant- induced arthritis (reduced cumulative disease scores and paw edema), and in the mouse model of collagen antibody-induced arthritis (Reduced clinical paw scores) to strengthen the possibility that HE3 286 may represent an effective anti-inflammatory agent useful for treating chronic inflammation with a more attractive safety profile than glucocorticoids or cyclooxygenase inhibitors.
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- Biology, MedicineInternational journal of clinical and experimental medicine
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- Biology, MedicinePloS one
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Network analysis revealed associations of these HE3286 target proteins with nodes in the Kyoto Encyclopedia of Genes and Genomes pathways for type 2 diabetes, insulin, adipokine, and adipocyte signaling.
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease
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17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain…
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