A New Neolignan and a New Sesterterpenoid from the Stems of Picrasma quassioides Bennet

  title={A New Neolignan and a New Sesterterpenoid from the Stems of Picrasma quassioides Bennet},
  author={Wei-Hua Jiao and Hao Gao and Feng Zhao and Fei He and Guang-xiong Zhou and Xin-sheng Yao},
  journal={Chemistry \& Biodiversity},
A new dihydrobenzofuran‐type neolignan, picrasmalignan A (1), and a new sesterterpene lactone, 2′‐isopicrasin A (4), were isolated from the stems of Picrasma quassioides Bennet, along with four known compounds, comprising two neolignans, 2 and 3, a sesterterpene lactone, 5, and a flavonol, 6. The structures of these compounds were determined by detailed analysis of NMR and MS data, and comparison with the literature data. Compounds 1–6 were tested for their anti‐inflammatory activity, and 1–3… 
Quassinoids from Picrasma quassioides and Their Neuroprotective Effects.
Eight new and 15 known quassinoids were isolated from an extract of the stems of Picrasma quassioides and it was revealed that the potential protective activities of these compounds appeared to occur via the suppression of cell apoptosis and downregulation of caspase-3 activation.
A New Triterpenoid from the Aerial Parts of Agrimonia pilosa
Compound 1 was the first example of a 28-norursene backbone isolated from the genus Agrimonia, and a plausible biosynthetic pathway for compound 1 in A. pilosa was also proposed.
Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1.
Investigation on the fruits of Melia toosendan afforded seven new lignans (1-7), along with seventeen known compounds (8-24), and the structures of the new compounds were elucidated based on extensive spectroscopic analyses.
Effects of Enantiomerically Pure β-Carboline Alkaloids from Picrasma quassioides on Human Hepatoma Cells.
Four pairs of β-carboline enantiomers with a single enantiomeric configuration, together with 2 known achiral congeners, were isolated from the stems of Picrasma quassioides and screened for their cytotoxicity against hepatocellular carcinoma Hep3B and HepG2 cells, which revealed that enantomeric compounds 4A: and 4B: had distinctive effects in HepG 2 cells.
In vitro anti-inflammatory effects of beta-carboline alkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway.
Results indicated that potent inhibition of nitric oxide, TNF-α, and IL-6, but not COx-2 expression and COX-2 activity, might constitute the anti-inflammatory mechanism of β-carboline alkaloids.


Quassidines A-D, bis-beta-carboline alkaloids from the stems of Picrasma quassioides.
Four new bis-beta-carboline alkaloids, quassidines A-D (1-4), together with a known alkaloid, picrasidine C (5), were isolated from the stems of Picrasma quassioides. Quassidine A (1) is the first
Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents
Two new alkaloids, 4, 9-dimethoxy-1-vinyl-β-carboline (XI) and β-carbolin-1-yl 3-(4, 8-dimethoxy-β-carbolin-1-yl)-1-methoxypropyl ketone (XII) were isolated from the wood of Picrasma quassioides
Isolation and characterization of new lignans from the leaves of Cestrum parqui
Three new compounds, a sesquilignans, an oxyneolignan and a norlignan, have been isolated from the aqueous fraction of Cestrum parqui and tested on the species Lactuca sativa and Lycopersicon esculentum to evaluate their phytotoxic activity.
Picrasinol C a New Quassinoid, and Its Related Compounds from the Stem Wood of Picrasma ailanthoides
A new quassinoid, picrasinol C[1], and twelve known quassinoids have been isolated from the stem wood of Picrasma ailanithoides. The structures of these compounds were elucidated from spectral
β‐Carboline alkaloids from the stems of Picrasma quassioides
The bioassays showed that only compounds 14 and 16 could enhance the differentiation of 3T3‐L1 preadiocytes accompanied by secretion of adiponectin proteins among these 23 compounds.
Antioxidant Lignans from the Fruits of Broussonetia papyrifera.
Nine new lignans, chushizisins A-I (1-9), and three known lignans, threo-1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol (10),
  • Prod. Res. 2006, 20, 293. Received May 14, 2010 CHEMISTRY & BIODIVERSITY – Vol. 8
  • 2011