A New Murine Model of Osteoblastic/Osteolytic Lesions from Human Androgen-Resistant Prostate Cancer

@inproceedings{Fradet2013ANM,
  title={A New Murine Model of Osteoblastic/Osteolytic Lesions from Human Androgen-Resistant Prostate Cancer},
  author={Ana{\"i}s Fradet and H{\'e}l{\`e}ne Sorel and Baptiste Depalle and Claire Marie Serre and Delphine Farlay and Andrei Turtoi and Akeila Bellahc{\'e}ne and H{\'e}l{\`e}ne Follet and Vincent Castronovo and Philippe Cl{\'e}zardin and Edith Bonnelye},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Up to 80% of patients dying from prostate carcinoma have developed bone metastases that are incurable. Castration is commonly used to treat prostate cancer. Although the disease initially responds to androgen blockade strategies, it often becomes castration-resistant (CRPC for Castration Resistant Prostate Cancer). Most of the murine models of mixed lesions derived from prostate cancer cells are androgen sensitive. Thus, we established a new model of CRPC (androgen receptor (AR… CONTINUE READING

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