A New Multigene Family of Putative Pheromone Receptors

  title={A New Multigene Family of Putative Pheromone Receptors},
  author={Nicholas J. P. Ryba and Roberto Tirindelli},

Figures and Tables from this paper

A Novel Family of Candidate Pheromone Receptors in Mammals
Pheromone detection mediated by a V1r vomeronasal receptor
It is shown at the single-cell level that V1r receptors are involved in chemodetection and identify a specific receptor–agonist pair in the vomeronasal system.
Sensory coding of pheromone signals in mammals
  • C. Dulac
  • Biology
    Current Opinion in Neurobiology
  • 2000
A putative pheromone receptor gene expressed in human olfactory mucosa
It is shown that pheromonal effects have been demonstrated in humans, and the V1R or V2R counterparts of the rodent genes have yet to be characterized.
Co-Expression of Putative Pheromone Receptors in the Sensory Neurons of the Vomeronasal Organ
The results suggest that different modes of the information processing may occur in the main and accessory olfactory systems.
Advances in research of mammalian vomeronasal pheromone perception and genetic components unique to vomeronasal signal transduction pathway
This review focuses on the recent advances on research in mammalian vomeronasal pheromone perception and those genetic components unique to vomer onasal signal transduction pathway, including vomerOnasal receptor V1R and V2R gene families as well as transient receptor potential channel 2 gene (TRPC2).
Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ
A third family of mouse VNO receptors comprising 5 of 7 members of the formyl peptide receptor (FPR) family are reported, like other FPRs, which function in the immune system, but are selectively expressed in VNO neurons in patterns strikingly similar to those of V1Rs and V2Rs.
The genomic basis of vomeronasal-mediated behaviour
The vomeronasal organ mediates a range of social behaviours, including male–male and maternal aggression, sexual attraction, lordosis, and selective pregnancy termination, as well as interspecific responses such as avoidance and defensive behaviours.


Sensory transduction in vomeronasal neurons: evidence for G alpha o, G alpha i2, and adenylyl cyclase II as major components of a pheromone signaling cascade
  • A. Berghard, L. Buck
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
The findings suggest that spatially segregated subsets of VNO neurons may use different, but related, sensory transduction pathways in which G-proteins and an adenylyl cyclase play major roles.
Molecular cloning of odorant-binding protein: member of a ligand carrier family.
Three complementary DNAs encoding rat odorant-binding protein have now been cloned and sequenced, and RNA blot analysis confirms the localization of OBP messenger RNA in the nasal epithelium.
Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs.
In mammals, olfactory stimuli are detected by sensory neurons at two distinct sites: the olfactory epithelium (OE) of the nasal cavity and the neuroepithelium of the vomeronasal organ (VNO). While
Vomeronasal system, LHRH, and sex behaviour
Golf: an olfactory neuron specific-G protein involved in odorant signal transduction.
Evidence is presented suggesting that this G protein, termed Golf, mediates olfaction, and the expression of Golf alpha in S49 cyc- kin- cells, a line deficient in endogenous stimulatory G proteins, demonstrates its capacity to stimulate adenylate cyclase in a heterologous system.