A New Method of Bone Tissue Measurement Based upon Light Scattering

  title={A New Method of Bone Tissue Measurement Based upon Light Scattering},
  author={Akira Takeuchi and Ryuichiro Araki and Sergey G. Proskurin and Y Takahashi and Y. Yamada and Jun Ishii and S Katayama and Akira Itabashi},
  journal={Journal of Bone and Mineral Research},
In recent years, time‐resolved spectroscopy systems using near infrared pulsed laser have been applied to develop optical computed tomography. We applied this technique to measure the optical properties of osseous tissue. First, we gradually demineralized 10 mm blocks of bovine trabecular bone with EDTA, maintaining the absorption characteristics and structure but varying the hydroxyapatite content, thus creating specimens differing only in light scattering properties. We used computer… 
Measurement of bone mineral density via light scattering.
The results suggest that minimally invasive techniques for measuring optical scattering, such as OCT, may have a role in monitoring regional changes in BMD and suggest that light transport in bone is spatially anisotropic.
Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies.
The capability to noninvasively quantify bone tissue composition suggests a possible use of optical biopsy for the diagnosis of bone pathologies such as osteoporosis, which are characterized by a progressive reduction and transformation of the mineral in the bone matrix.
Estimation of bone-mineral density from OCT images
Previously we have demonstrated by an integrating-sphere technique a useful correlation between bone mineral density (BMD) and the optical scattering coefficient (μs). We have used OCT to study this
The propagation of ps-laser-pulses through different bone structures
First results of angle and time resolved light scattering measurements performed on normal and osteoporotic human bone tissue are presented. The principle of measurement is based on time-correlated
Optical studies of changes in bone mineral density
The ability to measure changes in bone-mineral-density (BMD) in-vivo has potential applications in monitoring stress-induced bone remodelling in, for example, competition race horses. In this study
Photothermal tomography for the functional and structural evaluation, and early mineral loss monitoring in bones
The absolute nature and early demineralization-detection capability of a marker called thermal wave occupation index, estimated using the proposed modality, have been established and Selective imaging of regions of a specific mineral density range has been demonstrated in a mouse femur.
The impact of morphology on light transport in cancellous bone.
The average optical properties of cancellous bone are strongly determined by its microstructure, meaning that optical techniques are a valid method for tissue evaluation, but careful consideration of structure-related perturbation sources is required.
Bone Densitometry using Near-infrared Spectroscopy
The purpose of this study is to investigate the optical absorbance spectrum of bone tissue in the near-infrared region for the development of bone densitometry using near-infrared light. Using bone
Dynamic photophysical processes in laser irradiated human cortical skull bone
Modulated luminescence (LUM) technique was applied to analyze photophysical processes in the cortical layer of human skull bones. The theoretical interpretation of the results was based on the
Non-Destructive Optical Monitoring for Calcification of Tissue-Engineered Bone In Vitro
In this study, a non destructive monitoring system for osteoblastic calcification in tissue-engineered bone in vitro was proposed and developed utilizing near-infrared light. The system consists of


Analysis of tissue optical coefficients using an approximate equation valid for comparable absorption and scattering.
A new model of light propagation in tissue is shown to be accurate for arbitrary ratios of absorption and scattering, by comparison with a rigorous solution to the transport equation, which may be important in future applications of photodynamic therapy.
Measurement of the optical properties of the skull in the wavelength range 650-950 nm.
The optical properties of samples of bone from pig skull have been measured over the wavelength range 650-950 nm and the scattering and absorption coefficients, mu s and mu a, were determined from measurements of diffuse reflectance and transmittance made with a pair of integrating spheres.
Phase modulation system for dual wavelength difference spectroscopy of hemoglobin deoxygenation in tissues
Time resolved spectroscopy of tissue makes it possible to quantify tissue hemoglobin concentrations because of the direct measurement of the optical path length for photon migration. However, the
Bone density at various sites for prediction of hip fractures
Bone density of the femoral neck was a better predictor than measurements of the spine, radius, radius), radius, and moderately better than the calcaneus of hip fracture than those of other bones.
Monte Carlo simulation of light transport through inhomogeneous tissue
Quantitation of near infrared spectroscopic (NIRS) data requires an accurate knowledge of the effective optical pathlengths within the various components of an inhomogeneous scattering medium. For
Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis.
It is concluded that fluoride therapy increases cancellous but decreases cortical bone mineral density and increases skeletal fragility, and the fluoride-calcium regimen was not effective treatment for postmenopausal osteoporosis.
Monte Carlo simulation of light transmission through living tissues.
Temporal analyses of the transmittance have illustrated that the differences in the optical density among the slabs having different absorption coefficients with the same scattering coefficient vary linearly with time, thus verifying the microscopic Beer-Lambert law in highly scattering media when temporally resolved measurement is used.
Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties.
A simple model is developed, based on the diffusion approximation to radiative transfer theory, which yields analytic expressions for the pulse shape in terms of the interaction coefficients of a homogeneous slab.
Quantitative computed tomography for spinal density measurement. Factors affecting precision.
Quantitative computed tomography was performed in duplicate on 84 patients to test the short-term precision of the technique and it was revealed that precision was not a function of spinal density.
Simulation of fan-beam-type optical computed-tomography imaging of strongly scattering and weakly absorbing media.
A hybrid calculation scheme of scattering by the Monte Carlo method is employed to obtain the temporal variation of transmittance of the light impulse through the media and the reconstructed image of the difference in the absorption coefficient has better accuracy and spatial resolution than those images by the time-gating method.