A New Method of Bone Tissue Measurement Based upon Light Scattering

@article{Takeuchi1997ANM,
  title={A New Method of Bone Tissue Measurement Based upon Light Scattering},
  author={Akira Takeuchi and Ryuichiro Araki and Sergey G. Proskurin and Y Takahashi and Y. Yamada and Jun Ishii and S Katayama and Akira Itabashi},
  journal={Journal of Bone and Mineral Research},
  year={1997},
  volume={12}
}
In recent years, time‐resolved spectroscopy systems using near infrared pulsed laser have been applied to develop optical computed tomography. We applied this technique to measure the optical properties of osseous tissue. First, we gradually demineralized 10 mm blocks of bovine trabecular bone with EDTA, maintaining the absorption characteristics and structure but varying the hydroxyapatite content, thus creating specimens differing only in light scattering properties. We used computer… 
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References

SHOWING 1-10 OF 20 REFERENCES
Analysis of tissue optical coefficients using an approximate equation valid for comparable absorption and scattering.
TLDR
A new model of light propagation in tissue is shown to be accurate for arbitrary ratios of absorption and scattering, by comparison with a rigorous solution to the transport equation, which may be important in future applications of photodynamic therapy.
Measurement of the optical properties of the skull in the wavelength range 650-950 nm.
TLDR
The optical properties of samples of bone from pig skull have been measured over the wavelength range 650-950 nm and the scattering and absorption coefficients, mu s and mu a, were determined from measurements of diffuse reflectance and transmittance made with a pair of integrating spheres.
Phase modulation system for dual wavelength difference spectroscopy of hemoglobin deoxygenation in tissues
Time resolved spectroscopy of tissue makes it possible to quantify tissue hemoglobin concentrations because of the direct measurement of the optical path length for photon migration. However, the
Bone density at various sites for prediction of hip fractures
TLDR
Bone density of the femoral neck was a better predictor than measurements of the spine, radius, radius), radius, and moderately better than the calcaneus of hip fracture than those of other bones.
Monte Carlo simulation of light transport through inhomogeneous tissue
Quantitation of near infrared spectroscopic (NIRS) data requires an accurate knowledge of the effective optical pathlengths within the various components of an inhomogeneous scattering medium. For
Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis.
TLDR
It is concluded that fluoride therapy increases cancellous but decreases cortical bone mineral density and increases skeletal fragility, and the fluoride-calcium regimen was not effective treatment for postmenopausal osteoporosis.
Monte Carlo simulation of light transmission through living tissues.
TLDR
Temporal analyses of the transmittance have illustrated that the differences in the optical density among the slabs having different absorption coefficients with the same scattering coefficient vary linearly with time, thus verifying the microscopic Beer-Lambert law in highly scattering media when temporally resolved measurement is used.
Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties.
TLDR
A simple model is developed, based on the diffusion approximation to radiative transfer theory, which yields analytic expressions for the pulse shape in terms of the interaction coefficients of a homogeneous slab.
Quantitative computed tomography for spinal density measurement. Factors affecting precision.
TLDR
Quantitative computed tomography was performed in duplicate on 84 patients to test the short-term precision of the technique and it was revealed that precision was not a function of spinal density.
Simulation of fan-beam-type optical computed-tomography imaging of strongly scattering and weakly absorbing media.
TLDR
A hybrid calculation scheme of scattering by the Monte Carlo method is employed to obtain the temporal variation of transmittance of the light impulse through the media and the reconstructed image of the difference in the absorption coefficient has better accuracy and spatial resolution than those images by the time-gating method.
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