A New Method for the Preparation of Oxazaborolidine Catalyst In Situ Using 1 , 2-Aminoalcohol , Sodium Borohydride , and Diiodomethane for the Asymmetric Reduction of Prochiral Ketones and N-Substituted Imines

@inproceedings{Kettouche2009ANM,
  title={A New Method for the Preparation of Oxazaborolidine Catalyst In Situ Using 1 , 2-Aminoalcohol , Sodium Borohydride , and Diiodomethane for the Asymmetric Reduction of Prochiral Ketones and N-Substituted Imines},
  author={Hichem Sadrik Kettouche and Abdel Hafid Djerourou},
  year={2009}
}
  • Hichem Sadrik Kettouche, Abdel Hafid Djerourou
  • Published 2009
An oxazaborolidine catalyst is readily prepared in situ at room temperature in THF using 1,2-aminoalcohols and borane generated from sodium borohydride/CH2I2 reagent system. The oxazaborolidine/BH3 reagent system prepared in this way is useful for the reduction of prochiral ketones and N-substituted imines to the corresponding alcohols and amines with… CONTINUE READING