A New Internal Mode in F-Actin Helps Explain the Remarkable Evolutionary Conservation of Actin's Sequence and Structure

@article{Galkin2002ANI,
  title={A New Internal Mode in F-Actin Helps Explain the Remarkable Evolutionary Conservation of Actin's Sequence and Structure},
  author={Vitold E Galkin and M S Vanloock and Albina Orlova and Edward H. Egelman},
  journal={Current Biology},
  year={2002},
  volume={12},
  pages={570-575}
}
Actin is one of the most highly conserved eukaryotic proteins. There are no amino acid changes between the chicken and human skeletal muscle isoforms, and the most dissimilar actins still share more than 85% sequence identity [1]. We suggest that large discrete internal modes of freedom within the actin filament may account for a significant component of this conservation, since each subunit must make multiple specific interactions with neighboring subunits. In support of this, we find that the… CONTINUE READING

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