A New Insight into Structural and Functional Impact of Single-Nucleotide Polymorphisms in PTEN Gene

@article{Doss2012ANI,
  title={A New Insight into Structural and Functional Impact of Single-Nucleotide Polymorphisms in PTEN Gene},
  author={C. George Priya Doss and B. Rajith},
  journal={Cell Biochemistry and Biophysics},
  year={2012},
  volume={66},
  pages={249-263}
}
Phosphatase and tensin homolog (PTEN) plays essential roles in cellular processes including survival, proliferation, energy metabolism, and cellular architecture. Activating the mutations of PTEN has long been known to produce a variety of disorders, mainly diabetes and cancer in humans. Owing to the importance of PTEN gene, a functional analysis using different in silico approaches was undertaken to explore the possible associations between genetic mutations and phenotypic variation. SIFT… CONTINUE READING

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