A New In Situ Brain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation

@article{Avdeef2010ANI,
  title={A New In Situ Brain Perfusion Flow Correction Method for Lipophilic Drugs Based on the pH-Dependent Crone-Renkin Equation},
  author={Alex Avdeef and Na Sun},
  journal={Pharmaceutical Research},
  year={2010},
  volume={28},
  pages={517-530}
}
ABSTRACTPurposeTo determine the flow-corrected luminal permeability, Pc, of lipophilic drugs measured by the in situ brain perfusion method under circumstances where the traditional Crone-Renkin equation (CRE) method, using diazepam as a flow marker, often fails.MethodsThe pH-dependent rate of brain penetration of five lipophilic drugs (amitriptyline, atomoxetine, imipramine, indomethacin, maprotiline, sertraline), as well as of atenolol and antipyrine, were measured in Sprague-Dawley rats. A… CONTINUE READING
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